Suzetrigine|Resmetirom|Gepotidacin|Delgocitinib|Xanomeline--Cobridge Pharmaceutical

Pharmaceutical Intermediates

Product Name	Cas No.	Remark
6-(4-amino-2,6-dichlorophenoxy)-4-isopropylpyridazin -3(2H)-one	920509-28-0	Resmetirom
3,6-DICHLORO-4-ISOPROPYLPYRIDAZINE	107228-51-3	Resmetirom
3,5-DICHLORO-4-((6-CHLORO-5-ISOPROPYLPYRIDAZIN -3-YL)OXY)A NILINE	920509-27-9	Resmetirom
(Z)-ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyrid azin-3-yl)oxy)phenyl)hydrazono)acetyl)carbamate	920509-33-7	Resmetirom
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde	881674-56-2	Vonoprazan
5-(2-FLUOROPHENYL)-1-(PYRIDIN-2-YLSULFONYL)-1H-PYRROLE-3- CARBALDEHYDE	928324-73-6	Vonoprazan
2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile	312307-38-3	Vonoprazan
2'-Fluoroacetophenone	445-27-2	Vonoprazan
pyridine-3-sulfonyl chloride	16133-25-8	Vonoprazan
N-[(1R)-2-[1,1'-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester	1426129-50-1	Sacubitril
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino) -2- Methylpentanoic acid	1012341-50-2	Sacubitril
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride	149690-12-0	Sacubitril
Sacubitril Calcium	1369773-39-6	Sacubitril
(1R,2R)-1,2- Cyclohexanedimethanol	65376-05-8	Lurasidone
(1S,5R,6S)-Ethyl 5-(pentan-3-yl-oxy)-7-oxa-bicyclo[4.1.0]hept -3-ene-3-carboxylate	204254-96-6	Oseltamivir
(3R,4R,5S)-4-N-Acetyl(1,1-dimethylethyl)amino -5-N,N-diallylamin o-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester monohydrochloride	651324-08-2	Oseltamivir
(1R,3S)-3-AMinocyclopentanol hydrochloride	1279032-31-3	Bictegravir
Semaglutide N-1	1169630-82-3	Semaglutide
(R)-3-Amino-1-butanol	61477-40-5	Dolutegravir
2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro -3aH-cyclopen ta[d][1,3]dioxol-4-yloxy)ethanol L-	376608-65-0	Ticagrelor
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine Hydrochloride	1156491-10-9	Ticagrelor
4,6-Dichloro-2-(propylthio)pyrimidin -5-amine	145783-15-9	Ticagrelor
(2'R)- 2'-deoxy-2'-fluoro-2'-methyl- Uridine	863329-66-2	Sofosbuvir
((2R,3R,4R,5R)-5-(benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyl oxymethyl)-4-fluoro-4-	817204-32-3	Sofosbuvir
L-alanine,N-[(S)-(2,3,4,5,6-pentafluorophenoxy) -phenoxy-phosphi nyl]-1-Methylethyl ester	1334513-02-8	Sofosbuvir
N-[(2'-Cyanobiphenyl-4-methyl)-(L)-Valine methyl ester Hydrochloride	482577-59-3	Valsartan
Valsartan Methyl Ester	137863-17-3	Valsartan
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofur an-3-ylmethyl ester	149809-43-8	Posaconazole
(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyri midin-4-amine dihydrochloride	1701403-10-2	Ibrutinib
(5S)-4,5-O-(1-Methylethylidene)-1-C-4-morpholinyl-D-xylo-pentodi aldo-5,2-furanose	1103738-19-7	Sotagliflozin

Product Name
6-(4-amino-2,6-dichlorophenoxy)-4-isopropylpyridazin -3(2H)-one Cas no.: 920509-28-0 Remark: Resmetirom
3,6-DICHLORO-4-ISOPROPYLPYRIDAZINE Cas no.: 107228-51-3 Remark: Resmetirom
3,5-DICHLORO-4-((6-CHLORO-5-ISOPROPYLPYRIDAZIN -3-YL)OXY)A NILINE Cas no.: 920509-27-9 Remark: Resmetirom
(Z)-ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyrid azin-3-yl)oxy)phenyl)hydrazono)acetyl)carbamate Cas no.: 920509-33-7 Remark: Resmetirom
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Cas no.: 881674-56-2 Remark: Vonoprazan
5-(2-FLUOROPHENYL)-1-(PYRIDIN-2-YLSULFONYL)-1H-PYRROLE-3- CARBALDEHYDE Cas no.: 928324-73-6 Remark: Vonoprazan
2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile Cas no.: 312307-38-3 Remark: Vonoprazan
2'-Fluoroacetophenone Cas no.: 445-27-2 Remark: Vonoprazan
pyridine-3-sulfonyl chloride Cas no.: 16133-25-8 Remark: Vonoprazan
N-[(1R)-2-[1,1'-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester Cas no.: 1426129-50-1 Remark: Sacubitril
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino) -2- Methylpentanoic acid Cas no.: 1012341-50-2 Remark: Sacubitril
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride Cas no.: 149690-12-0 Remark: Sacubitril
Sacubitril Calcium Cas no.: 1369773-39-6 Remark: Sacubitril
(1R,2R)-1,2- Cyclohexanedimethanol Cas no.: 65376-05-8 Remark: Lurasidone
(1S,5R,6S)-Ethyl 5-(pentan-3-yl-oxy)-7-oxa-bicyclo[4.1.0]hept -3-ene-3-carboxylate Cas no.: 204254-96-6 Remark: Oseltamivir
(3R,4R,5S)-4-N-Acetyl(1,1-dimethylethyl)amino -5-N,N-diallylamin o-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester monohydrochloride Cas no.: 651324-08-2 Remark: Oseltamivir
(1R,3S)-3-AMinocyclopentanol hydrochloride Cas no.: 1279032-31-3 Remark: Bictegravir
Semaglutide N-1 Cas no.: 1169630-82-3 Remark: Semaglutide
(R)-3-Amino-1-butanol Cas no.: 61477-40-5 Remark: Dolutegravir
2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro -3aH-cyclopen ta[d][1,3]dioxol-4-yloxy)ethanol L- Cas no.: 376608-65-0 Remark: Ticagrelor
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine Hydrochloride Cas no.: 1156491-10-9 Remark: Ticagrelor
4,6-Dichloro-2-(propylthio)pyrimidin -5-amine Cas no.: 145783-15-9 Remark: Ticagrelor
(2'R)- 2'-deoxy-2'-fluoro-2'-methyl- Uridine Cas no.: 863329-66-2 Remark: Sofosbuvir
((2R,3R,4R,5R)-5-(benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyl oxymethyl)-4-fluoro-4- Cas no.: 817204-32-3 Remark: Sofosbuvir
L-alanine,N-[(S)-(2,3,4,5,6-pentafluorophenoxy) -phenoxy-phosphi nyl]-1-Methylethyl ester Cas no.: 1334513-02-8 Remark: Sofosbuvir
N-[(2'-Cyanobiphenyl-4-methyl)-(L)-Valine methyl ester Hydrochloride Cas no.: 482577-59-3 Remark: Valsartan
Valsartan Methyl Ester Cas no.: 137863-17-3 Remark: Valsartan
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofur an-3-ylmethyl ester Cas no.: 149809-43-8 Remark: Posaconazole
(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyri midin-4-amine dihydrochloride Cas no.: 1701403-10-2 Remark: Ibrutinib
(5S)-4,5-O-(1-Methylethylidene)-1-C-4-morpholinyl-D-xylo-pentodi aldo-5,2-furanose Cas no.: 1103738-19-7 Remark: Sotagliflozin

Product Name

6-(4-amino-2,6-dichlorophenoxy)-4-isopropylpyridazin -3(2H)-one
Cas no.: 920509-28-0
Remark: Resmetirom

3,6-DICHLORO-4-ISOPROPYLPYRIDAZINE
Cas no.: 107228-51-3
Remark: Resmetirom

3,5-DICHLORO-4-((6-CHLORO-5-ISOPROPYLPYRIDAZIN -3-YL)OXY)A NILINE
Cas no.: 920509-27-9
Remark: Resmetirom

(Z)-ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyrid azin-3-yl)oxy)phenyl)hydrazono)acetyl)carbamate
Cas no.: 920509-33-7
Remark: Resmetirom

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Cas no.: 881674-56-2
Remark: Vonoprazan

5-(2-FLUOROPHENYL)-1-(PYRIDIN-2-YLSULFONYL)-1H-PYRROLE-3- CARBALDEHYDE
Cas no.: 928324-73-6
Remark: Vonoprazan

2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile
Cas no.: 312307-38-3
Remark: Vonoprazan

2'-Fluoroacetophenone
Cas no.: 445-27-2
Remark: Vonoprazan

pyridine-3-sulfonyl chloride
Cas no.: 16133-25-8
Remark: Vonoprazan

N-[(1R)-2-[1,1'-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester
Cas no.: 1426129-50-1
Remark: Sacubitril

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino) -2- Methylpentanoic acid
Cas no.: 1012341-50-2
Remark: Sacubitril